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GHB (Gamma-Hydroxybutyric Acid) is a hydroxylated form of the short-chain fatty acid. Laborit was interested in studying the action of GABA in the nervous system, but GABA was known to be unable to cross the blood-brain barrier. However, GHB turned out to be pharmacologiy distinct in many of its actions from GABA, even though later research showed that GABA and GHB are interconvertible in the brain through a common metabolite- Succinic Semialdehyde (SSA). Somewhat surprisingly, in 1963 Bessman and Fishbein first reported GHB to be a naturally occurring molecule in the brain, and by 1970 the work of Roth and Giarman had proven conclusively that GHB is a normal, natural brain metabolite.


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