Physiological replacement of prednisone

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Glucocorticoids Dogs prednisone or prednisolone

T has been known since the mid 19th century that the adrenal cortex is essential for life.1 However, life-saving glucocorticoid replacement therapy for adrenal insufficiency (AI) was not widely available until the clinical introduction of cortisone in 1949.2 The initial standard of care established for glucocorticoid supplementation therapy during stress in hypoadrenal patients was based on early case reports of adrenal crises in patients not receiving adequate perioperative glucocorticoid coverage.34 Over the past decade, there has been a shift in clinical practice in favour of giving lower doses and shorter duration of glucocorticoids, according to the severity and duration of illness or surgery.57 The recommendations for glucocorticoid supplementation presented here will provide useful information for physicians, anaesthetists, surgeons, dentists, obstetricians and general practitioners.

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Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Chemiy, it is 17,21-dihydroxypregna-1, 4-diene-3,11, 20-trione and has the following structural formula: Prednisone is a white to practiy white, odorless, crystalline powder and has a molecular weht of 358.44. Prednisone is very slhtly soluble in water, slhtly soluble in alcohol, coroform, dioxane, and methanol.

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Each tablet, for oral administration, contains 5 mg or 10 mg of prednisone.

Physiological replacement of prednisone:

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